My laboratory studies the role of post-translational modifications and the antiviral host innate immune response. Our recent studies focus on the role of the tRNA methyltransferase TRMT1 as critical regulator of the innate immune response to bacterial infection through the modification of tRNA.My laboratory studies the role of post-translational modifications and the antiviral host innate immune response. Our recent studies focus on the role of the tRNA methyltransferase TRMT1 as critical regulator of the innate immune response to bacterial infection through the modification of tRNA.