Our lab explores the interactions between wild-type and dinucleotide-enriched viral RNA with host proteins, uncovering new insights into antiviral immune responses. Our work focuses on the development of live dinucleotide-enriched virus vaccines and oncolytic viruses, aiming to harness these engineered viruses for therapeutic applications. Additionally, we investigate flavivirus pathogenesis, including non-vector transmission and virus interactions with pregnant hosts and fetuses, providing critical knowledge for understanding and combating emerging infectious diseases.