Underlying heart and skeletal muscle diseases, with a primary focus on the role of RNA-binding proteins in regulating the expression of pathologic genes during stress challenges.
Editing and Modification of tRNA: Roles in Mitochondrial Biogenesis and Disease
RNA processing during vertebrate development; RNA decay; muscle-specific RNA splicing
Molecular mechanism and regulation of transcription
Roles of metal ions in RNA metabolism; ncRNAs
Viral pathogenesis, small RNA-directed chromatin methylation, viral suppression of transcriptional and post-transcriptional gene silencing
RNA-DNA complexation and functional modulation by synthetic bifacial peptide nucleic acid
Computational modeling of RNA structure and kinetics, RNA editing, sequence analysis
Epigenomic mechanisms that re-wire nuclear hormone receptor signalling in cancer
Mechanisms of alternative pre-mRNA splicing in the DNA damage response
James A Cowan
Structure and chemistry of RNA as a drug target and the design of novel metallopharmaceuticals against viral and pathogen RNA motifs
Protein-nucleic acid interactions, NMR spectroscopy, biophysical methods
Structure-function relationships in RNase P, a catalytic RNP complex
RNA Nanbiotechnology for siRNA/drug delivery; structure, function and applications of the RNA-geared phi29 DNA packaging nanomotor; single molecule imaging using Total Internal Reflection Fluorescence (TIRF) Microscopy and Optical Tweezers; single pore sensing using the connector of phi29 DNA packaging.
Tina M Henkin
How nascent transcripts recognize specific effectors and use that information to control gene expression
Paul K Herman
Regulation of eukaryotic cell proliferation; Functions of ribonucleoprotein complexes in quiescent cells
Jay B Hollick
Epigenetic mechanisms of gene control, Chromosome structure and function
Intracellular trafficking of RNA and proteins; Nucleus organization; RNA processing
Molecular mechanisms of tRNA processing enzymes
• Sugar sensing and signaling in higher plants • Plant hormone signal transduction • Post-transcriptional regulation of gene expression
Defining novel mechanisms of how mRNA translation is regulated and affected in human biology and disease.
Stephen J Kolb
RNA metabolism in neurological diseases
Role of IFN-stimulated genes in HIV, Ebolavirus and Zika virus infection, RNA virus assembly and release, viral oncogenesis and human lung cancer
Anchoring of Ran signal transduction in plants, Nuclear pore and nuclear envelope protein function, and Genomic a nalysis of long coiled-coil proteins
Studying the roles of RNA-binding proteins in controlling the oncogenic growth of cells lacking the Retinoblastoma 1 tumor-suppressor gene.
Aminoacyl-tRNA synthetases and nucleic acid-protein interactions in HIV
Our research interest focuses on elucidating the mechanism of microRNA (miRNA)-mediated gene regulations underlying cell type determination
Shahid M. Nimjee
My research focuses on the discovery and development of therapeutic RNAs to treat pathological thrombosis in treating diseases like stroke, carotid, cardiovascular and peripheral vascular disease.
Control of post-transcriptional gene expression by dynamic ribonucleoprotein (RNP) complexes
Phage ecology, evolution and discovery; Phage-host interaction biology via genome-wide ‘omics analyses
Research interest: Small RNA biology and mechanisms of epigenetic inheritance
Chromatin organization and dynamics; epigenetic regulation in normal and cancer cells
Translational control during Drosophila development