Center for RNA Biology Publications

Publications by James Cowan since 2000

• Lalintip Hocharoen and James A Cowan
  "Metallotherapeutics: Novel Strategies in Drug Design."
  Chemistry 15, 8670-8676 (2009).

• Yushi Liu and J A Cowan
  "Iron-Sulfur Cluster Biosynthesis: Characterization of a Molten Globule Domain in Human NFU."
  Biochemistry 48, 7512-8 (2009).

• Manunya Nuth and J A Cowan
  "Iron-sulfur cluster biosynthesis: characterization of IscU-IscS complex formation and a structural model for sulfide delivery to the 2Fe-2S assembly site."
  J. Biol. Inorg. Chem. 14, 829-39 (2009).

• Seth Bradford, Yuta Kawarasaki, and J A Cowan
  "Copper.Lys-Gly-His-Lys mediated cleavage of tRNAPhe: studies of reaction mechanism and cleavage specificity."
  J. Inorg. Biochem. 103, 871-5 (2009).

• Yushi Liu, Wenbin Qi, and J A Cowan
  "Iron-sulfur cluster biosynthesis: functional characterization of the N- and C-terminal domains of human NFU."
  Biochemistry 48, 973-80 (2009).

• Jia Huang, Eric Dizin, and J A Cowan
  "Mapping iron binding sites on human frataxin implications for cluster assembly on the ISU Fe-S cluster scaffold protein."
  J. Biol. Inorg. Chem. 13, 825-36 (2008).

• Nikhil H Gokhale, Seth Bradford, and J A Cowan
  "Catalytic inactivation of human carbonic anhydrase I by a metallopeptide-sulfonamide conjugate is mediated by oxidation of active site residues."
  J. Am. Chem. Soc. 130, 2388-9 (2008).

• Nikhil H Gokhale, Seth Bradford, and J A Cowan
  "Stimulation and oxidative catalytic inactivation of thermolysin by copper.Cys-Gly-His-Lys."
  J. Biol. Inorg. Chem. 12, 981-7 (2007).

• Yan Jin, Mark A Lewis, Nikhil H Gokhale, Eric C Long, and J A Cowan
  "Influence of stereochemistry and redox potentials on the single- and double-strand DNA cleavage efficiency of CuII and NiII Lys-Gly-His-derived ATCUN metallopeptides."
  J. Am. Chem. Soc. 129, 8353-61 (2007).

• Yan Jin and J A Cowan
  "Cellular activity of Rev response element RNA targeting metallopeptides."
  J. Biol. Inorg. Chem. 12, 637-44 (2007).

• Taejin Yoon, Eric Dizin, and J A Cowan
  "N-terminal iron-mediated self-cleavage of human frataxin regulation of iron binding and complex formation with target proteins."
  J. Biol. Inorg. Chem. 12, 535-42 (2007).

• Chun-An Chen and J A Cowan
  "Characterization of Saccharomyces cerevisiae Atm1p functional studies of an ABC7 type transporter."
  Biochim. Biophys. Acta 1760, 1857-65 (2006).

• Nikhil H Gokhale and J A Cowan
  "Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1 Toward dual-action therapeutics."
  J. Biol. Inorg. Chem. 11, 937-47 (2006).

• Yan Jin and J A Cowan
  "Targeted cleavage of HIV rev response element RNA by metallopeptide complexes."
  J. Am. Chem. Soc. 128, 410-1 (2006).

• Yan Jin and J A Cowan
  "DNA cleavage by copper-ATCUN complexes. Factors influencing cleavage mechanism and linearization of dsDNA."
  J. Am. Chem. Soc. 127, 8408-15 (2005).

• Shu-Pao Wu, Sheref S Mansy, and J A Cowan
  "Iron-sulfur cluster biosynthesis. Molecular chaperone DnaK promotes IscU-bound 2Fe-2S cluster stability and inhibits cluster transfer activity."
  Biochemistry 44, 4284-93 (2005).

• Sheref S Mansy and J A Cowan
  "Iron-sulfur cluster biosynthesis toward an understanding of cellular machinery and molecular mechanism."
  Acc. Chem. Res. 37, 719-25 (2004).

• Taejin Yoon and J A Cowan
  "Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis."
  J. Biol. Chem. 279, 25943-6 (2004).

• Sheref S Mansy, Shu-pao Wu, and J A Cowan
  "Iron-sulfur cluster biosynthesis biochemical characterization of the conformational dynamics of Thermotoga maritima IscU and the relevance for cellular cluster assembly."
  J. Biol. Chem. 279, 10469-75 (2004).

• Chun-An Chen and J A Cowan
  "Characterization of the soluble domain of the ABC7 type transporter Atm1."
  J. Biol. Chem. 278, 52681-8 (2003).

• Taejin Yoon and J A Cowan
  "Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of 2Fe-2S clusters in ISU-type proteins."
  J. Am. Chem. Soc. 125, 6078-84 (2003).

• Shu-pao Wu and J A Cowan
  "Iron-sulfur cluster biosynthesis. A comparative kinetic analysis of native and Cys-substituted ISA-mediated 2Fe-2S2 cluster transfer to an apoferredoxin target."
  Biochemistry 42, 5784-91 (2003).

• J A Cowan
  "Structural and catalytic chemistry of magnesium-dependent enzymes."
  Biometals 15, 225-35 (2002).

• Alavattam Sreedhara and J A Cowan
  "Structural and catalytic roles for divalent magnesium in nucleic acid biochemistry."
  Biometals 15, 211-23 (2002).

• Manunya Nuth, Taejin Yoon, and J A Cowan
  "Iron-sulfur cluster biosynthesis characterization of iron nucleation sites for assembly of the 2Fe-2S2 cluster core in IscU proteins."
  J. Am. Chem. Soc. 124, 8774-5 (2002).

• Shu-Pao Wu, Gong Wu, Kristene K Surerus, and J A Cowan
  "Iron-sulfur cluster biosynthesis. Kinetic analysis of 2Fe-2S cluster transfer from holo ISU to apo Fd role of redox chemistry and a conserved aspartate."
  Biochemistry 41, 8876-85 (2002).

• Sheref S Mansy, Gong Wu, Kristene K Surerus, and J A Cowan
  "Iron-sulfur cluster biosynthesis. Thermatoga maritima IscU is a structured iron-sulfur cluster assembly protein."
  J. Biol. Chem. 277, 21397-404 (2002).

• Gong Wu, Sheref S Mansy, Shu-pao Wu Sp, Kristene K Surerus, Matthew W Foster, and J A Cowan
  "Characterization of an iron-sulfur cluster assembly protein ISU1 from Schizosaccharomyces pombe."
  Biochemistry 41, 5024-32 (2002).

• Gong Wu, Sheref S Mansy, Craig Hemann, Russ Hille, Kristene K Surerus, and J A Cowan
  "Iron-sulfur cluster biosynthesis characterization of Schizosaccharomyces pombe Isa1."
  J. Biol. Inorg. Chem. 7, 526-32 (2002).

• Sheref S Mansy, Yong Xiong, Craig Hemann, Russ Hille, M Sundaralingam, and J A Cowan
  "Crystal structure and stability studies of C77S HiPIP a serine ligated 4Fe-4S cluster."
  Biochemistry 41, 1195-201 (2002).

• J A Cowan
  "Chemical nucleases."
  Current opinion in chemical biology 5, 634-42 (2001).

• U Puapaiboon, J Jai-Nhuknan, and J A Cowan
  "Characterization of a multi-functional metal-mediated nuclease by MALDI-TOF mass spectrometry."
  Nucleic Acids Res. 29, 3652-6 (2001).

• A Sreedhara and J A Cowan
  "Catalytic hydrolysis of DNA by metal ions and complexes."
  J. Biol. Inorg. Chem. 6, 337-47 (2001).

• M W Foster, S Bian, K K Surerus, and J A Cowan
  "Elucidation of a 4Fe-4S cluster degradation pathway rapid kinetic studies of the degradation of Chromatium vinosum HiPIP."
  J. Biol. Inorg. Chem. 6, 266-74 (2001).

• A Sreedhara and J A Cowan
  "Targeted site-specific cleavage of HIV-1 viral Rev responsive element by copper aminoglycosides."
  J. Biol. Inorg. Chem. 6, 166-72 (2001).

• J A Cowan, T Ohyama, D Wang, and K Natarajan
  "Recognition of a cognate RNA aptamer by neomycin B quantitative evaluation of hydrogen bonding and electrostatic interactions."
  Nucleic Acids Res. 28, 2935-42 (2000).

• U Puapaiboon, J Jai-nhuknan, and J A Cowan
  "Rapid and direct sequencing of double-stranded DNA using exonuclease III and MALDI-TOF MS."
  Anal. Chem. 72, 3338-41 (2000).

• J A Cowan, T Ohyama, K Howard, J W Rausch, S M Cowan, and S F Le Grice
  "Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry."
  J. Biol. Inorg. Chem. 5, 67-74 (2000).