Center for RNA Biology Publications

Publications by Danilo Perrotti since 2000

• J M Goldman, A R Green, T Holyoake, C Jamieson, R Mesa, T Mughal, F Pellicano, D Perrotti, R Skoda, and A M Vannucchi
  "Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues."
  Leukemia 23, 1708-15 (2009).

• Stefan Costinean, Sukhinder K Sandhu, Irene M Pedersen, Esmerina Tili, Rossana Trotta, Danilo Perrotti, David Ciarlariello, Paolo Neviani, Jason Harb, Lauren Rachel Kauffman, Aaditya Shidham, and Carlo Maria Croce
  "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice."
  Blood 114, 1374-82 (2009).

• Ramiro Garzon, Shujun Liu, Muller Fabbri, Zhongfa Liu, Catherine E A Heaphy, Elisa Callegari, Sebastian Schwind, Jiuxia Pang, Jianhua Yu, Natarajan Muthusamy, Violaine Havelange, Stefano Volinia, William Blum, Laura J Rush, Danilo Perrotti, Michael Andreeff, Clara D Bloomfield, John C Byrd, Kenneth Chan, Lai-Chu Wu, Carlo M Croce, and Guido Marcucci
  "MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1."
  Blood 113, 6411-8 (2009).

• Zhongfa Liu, Shujun Liu, Zhiliang Xie, Ryan E Pavlovicz, Jiejun Wu, Ping Chen, Josephine Aimiuwu, Jiuxia Pang, Deepak Bhasin, Paolo Neviani, James R Fuchs, Christoph Plass, Pui-Kai Li, Chenglong Li, Tim H-M Huang, Lai-Chu Wu, Laura Rush, Hongyan Wang, Danilo Perrotti, Guido Marcucci, and Kenneth K Chan
  "Modulation of DNA methylation by a sesquiterpene lactone parthenolide."
  J. Pharmacol. Exp. Ther. 329, 505-14 (2009).

• A K Samanta, S N Chakraborty, Y Wang, H Kantarjian, X Sun, J Hood, D Perrotti, and R B Arlinghaus
  "Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients."
  Oncogene 28, 1669-81 (2009).

• Don M Benson, Jianhua Yu, Brian Becknell, Min Wei, Aharon G Freud, Amy K Ferketich, Rossana Trotta, Danilo Perrotti, Roger Briesewitz, and Michael A Caligiuri
  "Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells."
  Blood 113, 2706-14 (2009).

• N C P Cross, G Q Daley, A R Green, T P Hughes, C Jamieson, P Manley, T Mughal, D Perrotti, J Radich, R Skoda, S Soverini, W Vainchenker, S Verstovsek, J-L Villeval, and J M Goldman
  "BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features."
  Leukemia 22, 1975-89 (2008).

• Rossana Trotta, Jessica Dal Col, Jianhua Yu, David Ciarlariello, Brittany Thomas, Xiaoli Zhang, Jeffrey Allard, Min Wei, Hsiaoyin Mao, John C Byrd, Danilo Perrotti, and Michael A Caligiuri
  "TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells."
  J. Immunol. 181, 3784-92 (2008).

• Danilo Perrotti and Paolo Neviani
  "Protein phosphatase 2A PP2A, a drugable tumor suppressor in Ph1 leukemias."
  Cancer Metastasis Rev. 27, 159-68 (2008).

• Shujun Liu, Zhongfa Liu, Zhiliang Xie, Jiuxia Pang, Jianhua Yu, Esther Lehmann, Lenguyen Huynh, Tamara Vukosavljevic, Mitsui Takeki, Rebecca B Klisovic, Robert A Baiocchi, William Blum, Pierluigi Porcu, Ramiro Garzon, John C Byrd, Danilo Perrotti, Michael A Caligiuri, Kenneth K Chan, Lai-Chu Wu, and Guido Marcucci
  "Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia."
  Blood 111, 2364-73 (2008).

• Anna M Eiring, Paolo Neviani, Ramasamy Santhanam, Joshua J Oaks, Ji Suk Chang, Mario Notari, William Willis, Carlo Gambacorti-Passerini, Stefano Volinia, Guido Marcucci, Michael A Caligiuri, Gustavo W Leone, and Danilo Perrotti
  "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics requirement of E2F3 for BCR/ABL leukemogenesis."
  Blood 111, 816-28 (2008).

• Qing Liu, Xiaobin Zhao, Frank Frissora, Yihui Ma, Ramasamy Santhanam, David Jarjoura, Amy Lehman, Danilo Perrotti, Ching-Shih Chen, James T Dalton, Natarajan Muthusamy, and John C Byrd
  "FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma."
  Blood 111, 275-84 (2008).

• Steffen Koschmieder, Francesco DAlò, Hanna Radomska, Christine Schöneich, Ji Suk Chang, Marina Konopleva, Susumu Kobayashi, Elena Levantini, Nanjoo Suh, Annalisa Di Ruscio, Maria Teresa Voso, Julie C Watt, Ramasamy Santhanam, Bülent Sargin, Hagop Kantarjian, Michael Andreeff, Michael B Sporn, Danilo Perrotti, Wolfgang E Berdel, Carsten Müller-Tidow, Hubert Serve, and Daniel G Tenen
  "CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha."
  Blood 110, 3695-705 (2007).

• Emily K Thomas, Jose A Cancelas, Hee-Don Chae, Adrienne D Cox, Patricia J Keller, Danilo Perrotti, Paolo Neviani, Brian J Druker, Kenneth D R Setchell, Yi Zheng, Chad E Harris, and David A Williams
  "Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease."
  Cancer Cell 12, 467-78 (2007).

• Annamaria Galietta, Rosalind H Gunby, Sara Redaelli, Paola Stano, Cristiana Carniti, Angela Bachi, Philip W Tucker, Carmen J Tartari, Ching-Jung Huang, Emanuela Colombo, Karen Pulford, Miriam Puttini, Rocco G Piazza, Holger Ruchatz, Antonello Villa, Arianna Donella-Deana, Oriano Marin, Danilo Perrotti, and Carlo Gambacorti-Passerini
  "NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma."
  Blood 110, 2600-9 (2007).

• Rossana Trotta, David Ciarlariello, Jessica Dal Col, Jeffrey Allard, Paolo Neviani, Ramasamy Santhanam, Hsiaoyin Mao, Brian Becknell, Jianhua Yu, Amy K Ferketich, Brittany Thomas, Aalok Modi, Bradley W Blaser, Danilo Perrotti, and Michael A Caligiuri
  "The PP2A inhibitor SET regulates natural killer cell IFN-gamma production."
  J. Exp. Med. 204, 2397-405 (2007).

• Paolo Neviani, Ramasamy Santhanam, Joshua J Oaks, Anna M Eiring, Mario Notari, Bradley W Blaser, Shujun Liu, Rossana Trotta, Natarajan Muthusamy, Carlo Gambacorti-Passerini, Brian J Druker, Jorge Cortes, Guido Marcucci, Ching-Shih Chen, Nicole M Verrills, Denis C Roy, Michael A Caligiuri, Clara D Bloomfield, John C Byrd, and Danilo Perrotti
  "FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia."
  J. Clin. Invest. 117, 2408-21 (2007).

• Ji Suk Chang, Ramasamy Santhanam, Rossana Trotta, Paolo Neviani, Anna M Eiring, Edward Briercheck, Mattia Ronchetti, Denis C Roy, Bruno Calabretta, Michael A Caligiuri, and Danilo Perrotti
  "High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation."
  Blood 110, 994-1003 (2007).

• Michael A Caligiuri, Roger Briesewitz, Jianhua Yu, Lisheng Wang, Min Wei, Kristy J Arnoczky, Trent B Marburger, Jing Wen, Danilo Perrotti, Clara D Bloomfield, and Susan P Whitman
  "Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia."
  Blood 110, 1022-4 (2007).

• Shujun Liu, Rebecca B Klisovic, Tamara Vukosavljevic, Jianhua Yu, Peter Paschka, Lenguyen Huynh, Jiuxia Pang, Paolo Neviani, Zhongfa Liu, William Blum, Kenneth K Chan, Danilo Perrotti, and Guido Marcucci
  "Targeting AML1/ETO-histone deacetylase repressor complex a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells."
  J. Pharmacol. Exp. Ther. 321, 953-60 (2007).

• Brian Becknell, Tiffany L Hughes, Aharon G Freud, Bradley W Blaser, Jianhua Yu, Rossana Trotta, Hsiaoyin C Mao, Marie L Caligiuri de Jesús, Mohamad Alghothani, Don M Benson, Amy Lehman, David Jarjoura, Danilo Perrotti, Michael D Bates, and Michael A Caligiuri
  "Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells."
  Blood 109, 2481-7 (2007).

• Danilo Perrotti and Paolo Neviani
  "From mRNA metabolism to cancer therapy chronic myelogenous leukemia shows the way."
  Clin. Cancer Res. 13, 1638-42 (2007).

• Zhongfa Liu, Shujun Liu, Zhiliang Xie, William Blum, Danilo Perrotti, Peter Paschka, Rebecca Klisovic, John Byrd, Kenneth K Chan, and Guido Marcucci
  "Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method."
  Nucleic Acids Res. 35, e31 (2007).

• Li Chen, Rulong Shen, Yin Ye, Xin-An Pu, Xingluo Liu, Wenrui Duan, Jing Wen, Jason Zimmerer, Ying Wang, Yan Liu, Larry C Lasky, Nyla A Heerema, Danilo Perrotti, Keiko Ozato, Satomi Kuramochi-Miyagawa, Toru Nakano, Allen J Yates, William E Carson, Haifan Lin, Sanford H Barsky, and Jian-Xin Gao
  "Precancerous stem cells have the potential for both benign and malignant differentiation."
  PLoS ONE 2, e293 (2007).

• D Perrotti and P Neviani
  "ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia."
  Br. J. Cancer 95, 775-81 (2006).

• Young-Jin Lee, Letetia C Jones, Nikolai A Timchenko, Danilo Perrotti, Daniel G Tenen, and Scott C Kogan
  "CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities."
  Blood 108, 2416-9 (2006).

• Peter Paschka, Guido Marcucci, Amy S Ruppert, Krzysztof Mrózek, Hankui Chen, Rick A Kittles, Tamara Vukosavljevic, Danilo Perrotti, James W Vardiman, Andrew J Carroll, Jonathan E Kolitz, Richard A Larson, Clara D Bloomfield, and Cancer and Leukemia Group B
  "Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv16 and t8;21: a Cancer and Leukemia Group B Study."
  J. Clin. Oncol. 24, 3904-11 (2006).

• Shih-Jiuan Chiu, Shujun Liu, Danilo Perrotti, Guido Marcucci, and Robert J Lee
  "Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide G3139 via transferrin receptor-targeted liposomes."
  Journal of controlled release official journal of the Controlled Release Society 112, 199-207 (2006).

• Clara Guerzoni, Michela Bardini, Samanta A Mariani, Giovanna Ferrari-Amorotti, Paolo Neviani, Maria Luisa Panno, Ying Zhang, Robert Martinez, Danilo Perrotti, and Bruno Calabretta
  "Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells."
  Blood 107, 4080-9 (2006).

• Mario Notari, Paolo Neviani, Ramasamy Santhanam, Bradley W Blaser, Ji-Suk Chang, Annamaria Galietta, Anne E Willis, Denis C Roy, Michael A Caligiuri, Guido Marcucci, and Danilo Perrotti
  "A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation."
  Blood 107, 2507-16 (2006).

• Guido Marcucci, Claudia D Baldus, Amy S Ruppert, Michael D Radmacher, Krzysztof Mrózek, Susan P Whitman, Jonathan E Kolitz, Colin G Edwards, James W Vardiman, Bayard L Powell, Maria R Baer, Joseph O Moore, Danilo Perrotti, Michael A Caligiuri, Andrew J Carroll, Richard A Larson, Albert de la Chapelle, and Clara D Bloomfield
  "Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype a Cancer and Leukemia Group B study."
  J. Clin. Oncol. 23, 9234-42 (2005).

• Paolo Neviani, Ramasamy Santhanam, Rossana Trotta, Mario Notari, Bradley W Blaser, Shujun Liu, Hsiaoyin Mao, Ji Suk Chang, Annamaria Galietta, Ashwin Uttam, Denis C Roy, Mauro Valtieri, Rebecca Bruner-Klisovic, Michael A Caligiuri, Clara D Bloomfield, Guido Marcucci, and Danilo Perrotti
  "The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein."
  Cancer Cell 8, 355-68 (2005).

• D Perrotti, F Turturro, and P Neviani
  "BCR/ABL, mRNA translation and apoptosis."
  Cell Death Differ. 12, 534-40 (2005).

• Shujun Liu, Tiansheng Shen, Lenguyen Huynh, Marko I Klisovic, Laura J Rush, Jamie L Ford, Jianhua Yu, Brian Becknell, Yu Li, Chunhui Liu, Tamara Vukosavljevic, Susan P Whitman, Kun-Sang Chang, John C Byrd, Danilo Perrotti, Christoph Plass, and Guido Marcucci
  "Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia."
  Cancer Res. 65, 1277-84 (2005).

• Bruno Calabretta and Danilo Perrotti
  "The biology of CML blast crisis."
  Blood 103, 4010-22 (2004).

• Danilo Perrotti and Bruno Calabretta
  "Translational regulation by the p210 BCR/ABL oncoprotein."
  Oncogene 23, 3222-9 (2004).

• Danilo Perrotti, Guido Marcucci, and Michael A Caligiuri
  "Loss of C/EBP alpha and favorable prognosis of acute myeloid leukemias: a biological paradox."
  J. Clin. Oncol. 22, 582-4 (2004).

• Karen Keeshan, Giorgia Santilli, Francesca Corradini, Danilo Perrotti, and Bruno Calabretta
  "Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation."
  Blood 102, 1267-75 (2003).

• Guido Marcucci, Danilo Perrotti, and Michael A Caligiuri
  "Understanding the molecular basis of imatinib mesylate therapy in chronic myelogenous leukemia and the related mechanisms of resistance. Commentary re A. N. Mohamed et al., The effect of imatinib mesylate on patients with Philadelphia chromosome-positive chronic myeloid leukemia with secondary chromosomal aberrations. Clin. Cancer Res., 9 1333-1337, 2003."
  Clin. Cancer Res. 9, 1248-52 (2003).

• Bao-Tran H Truong, Young-Jin Lee, Tracey A Lodie, Dorothy J Park, Danilo Perrotti, Naohide Watanabe, H Phillip Koeffler, Hideaki Nakajima, Daniel G Tenen, and Scott C Kogan
  "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia."
  Blood 101, 1141-8 (2003).

• Rossana Trotta, Tatiana Vignudelli, Olivia Candini, Robert V Intine, Luisa Pecorari, Clara Guerzoni, Giorgia Santilli, Mike W Byrom, Silvia Goldoni, Lance P Ford, Michael A Caligiuri, Richard J Maraia, Danilo Perrotti, and Bruno Calabretta
  "BCR/ABL activates mdm2 mRNA translation via the La antigen."
  Cancer Cell 3, 145-60 (2003).

• Danilo Perrotti, Rossana Trotta, and Bruno Calabretta
  "Altered mRNA translation possible mechanism for CML disease progression."
  Cell Cycle 2, 177-80 (2003).

• Danilo Perrotti and Bruno Calabretta
  "Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins."
  Oncogene 21, 8577-83 (2002).

• Angela Iervolino, Giorgia Santilli, Rossana Trotta, Clara Guerzoni, Vincenzo Cesi, Anna Bergamaschi, Carlo Gambacorti-Passerini, Bruno Calabretta, and Danilo Perrotti
  "hnRNP A1 nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR/ABL leukemogenesis."
  Mol. Cell. Biol. 22, 2255-66 (2002).

• Danilo Perrotti, Vincenzo Cesi, Rossana Trotta, Clara Guerzoni, Giorgia Santilli, Kenneth Campbell, Angela Iervolino, Fabrizio Condorelli, Carlo Gambacorti-Passerini, Michael A Caligiuri, and Bruno Calabretta
  "BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2."
  Nat. Genet. 30, 48-58 (2002).

• M Cirinnà, R Trotta, P Salomoni, P Kossev, M Wasik, D Perrotti, and B Calabretta
  "Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation."
  Blood 96, 3915-21 (2000).

• D Perrotti, A Iervolino, V Cesi, M Cirinná, S Lombardini, E Grassilli, S Bonatti, P P Claudio, and B Calabretta
  "BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS TLS proteolysis through a protein kinase CbetaII-dependent pathway."
  Mol. Cell. Biol. 20, 6159-69 (2000).

• D Venturelli, V Cesi, S Ransac, A Engelhard, D Perrotti, and B Calabretta
  "The nucleoside diphosphate kinase activity of DRnm23 is not required for inhibition of differentiation and induction of apoptosis in 32Dcl3 myeloid precursor cells."
  Exp. Cell Res. 257, 265-71 (2000).

• L Manzella, R Gualdi, D Perrotti, N C Nicolaides, G Girlando, M A Giuffrida, A Messina, and B Calabretta
  "The interferon regulatory factors 1 and 2 bind to a segment of the human c-myb first intron: possible role in the regulation of c-myb expression."
  Exp. Cell Res. 256, 248-56 (2000).