Underlying heart and skeletal muscle diseases, with a primary focus on the role of RNA-binding proteins in regulating the expression of pathologic genes during stress challenges.
Editing and Modification of tRNA: Roles in Mitochondrial Biogenesis and Disease
RNA processing during vertebrate development; RNA decay; muscle-specific RNA splicing
Molecular mechanism and regulation of transcription
Roles of metal ions in RNA metabolism; ncRNAs
Viral pathogenesis, small RNA-directed chromatin methylation, viral suppression of transcriptional and post-transcriptional gene silencing
RNA-DNA complexation and functional modulation by synthetic bifacial peptide nucleic acid
Computational modeling of RNA structure and kinetics, RNA editing, sequence analysis
Mechanisms of alternative pre-mRNA splicing in the DNA damage response
James A Cowan
Structure and chemistry of RNA as a drug target and the design of novel metallopharmaceuticals against viral and pathogen RNA motifs
Protein-nucleic acid interactions, NMR spectroscopy, biophysical methods
Structure-function relationships in RNase P, a catalytic RNP complex
Tina M Henkin
How nascent transcripts recognize specific effectors and use that information to control gene expression
Paul K Herman
Regulation of eukaryotic cell proliferation; Functions of ribonucleoprotein complexes in quiescent cells
Jay B Hollick
Epigenetic mechanisms of gene control, Chromosome structure and function
Intracellular trafficking of RNA and proteins; Nucleus organization; RNA processing
Protein synthesis in bacteria and archaea; antibiotic resistance
Molecular mechanisms of tRNA processing enzymes
Role of IFN-stimulated genes in HIV, Ebolavirus and Zika virus infection, RNA virus assembly and release, viral oncogenesis and human lung cancer
Anchoring of Ran signal transduction in plants, Nuclear pore and nuclear envelope protein function, and Genomic a nalysis of long coiled-coil proteins
Studying the roles of RNA-binding proteins in controlling the oncogenic growth of cells lacking the Retinoblastoma 1 tumor-suppressor gene.
Aminoacyl-tRNA synthetases and nucleic acid-protein interactions in HIV
Our research interest focuses on elucidating the mechanism of microRNA (miRNA)-mediated gene regulations underlying cell type determination
Shahid M. Nimjee
My research focuses on the discovery and development of therapeutic RNAs to treat pathological thrombosis in treating diseases like stroke, carotid, cardiovascular and peripheral vascular disease.
Daniel R Schoenberg
Fundamental aspects of mRNA metabolism and the role of mRNA decay in inherited genetic disorders and cancer
Control of post-transcriptional gene expression by dynamic ribonucleoprotein (RNP) complexes
R Keith Slotkin
My laboratory aims to discover how potentially mutagenic “jumping genes” or transposable elements are epigenetically repressed from generation to generation, as well as how this system has been adopted over evolutionary time to regulate non-transposable element genes.
Phage ecology, evolution and discovery; Phage-host interaction biology via genome-wide ‘omics analyses
Translational control during Drosophila development
Molecular mechanisms of HIV replication and host cell interactions.